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形狀
powder
包裝
pkg of 1 × 10 mg (860634P-10mg)
pkg of 1 × 5 mg (860634P-5mg)
製造商/商標名
Avanti Research™ - A Croda Brand 860634P
脂質類型
sphingolipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C34H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32-33,36-37H,3-31H2,1-2H3,(H,35,38)/t32-,33+/m0/s1
InChI 密鑰
GCGTXOVNNFGTPQ-JHOUSYSJSA-N
應用
C16二氢神经酰胺(d18:0/16:0)适用于研究在四氢大麻酚(THC)处理的细胞中自噬体和自溶酶体的鞘脂组成中观察到的变化的潜在相关性,或使生物膜不稳定。
生化/生理作用
二羟基神经酰胺是用于合成神经酰胺的前体。它具有诱导核周区域自噬的能力。二氢神经酰胺影响自噬通量并增强脂质滴的形成。C16-二氢神经酰胺的积累可能会导致肝损伤。
包裝
5 mL棕色玻璃螺旋盖小瓶(860634P-10mg)
5 mL棕色玻璃螺旋盖小瓶(860634P-5mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
也與該產品經常一起購買
产品编号
说明
价格
儲存類別代碼
11 - Combustible Solids
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Autophagy, 12(11), 2213-2229 (2016)
Langmuir : the ACS journal of surfaces and colloids, 32(23), 5973-5980 (2016-05-25)
To better understand the interactions of saturated ceramides with unsaturated glycerophospholipids in bilayer membranes, we measured how palmitoyl ceramide (PCer) and dihydroceramide (dihydro-PCer, lacking the trans 4 double bond of the sphingoid base of ceramide) can interact with phosphatidylcholines (PCs)
Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model
Biochemical and biophysical research communications, 494(3-4), 460-469 (2017)
Autophagy, 12(11), 2213-2229 (2016-11-02)
Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main
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