跳转至内容
Merck

860600P

Avanti

Lyso SM (d18:1)

Avanti Research - A Croda Brand 860600P, powder

别名:

鞘氨醇磷酸胆碱

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C23H49N2O5P
CAS号:
分子量:
464.62
分類程式碼代碼:
12352211
NACRES:
NA.25

形狀

powder

包裝

pkg of 1 × 10 mg (860600P-10mg)
pkg of 1 × 25 mg (860600P-25mg)
pkg of 1 × 5 mg (860600P-5mg)
pkg of 1 × 50 mg (860600P-50mg)

製造商/商標名

Avanti Research - A Croda Brand 860600P

脂質類型

sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(N)COP([O-])(OCC[N+](C)(C)C)=O

InChI

1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1

InChI 密鑰

JLVSPVFPBBFMBE-HXSWCURESA-N

一般說明

Lyso SM(d18:1),也称为鞘氨醇磷酸胆碱(SPC),是一种生物活性脂质分子。这种溶血磷脂存在于正常的血浆、腹水和各种组织中。

應用

Lyso SM(d18:1)已用于:
  • 通过平面脂质双层中的单通道记录来研究其在存在和不存在钙调蛋白的情况下对骨骼肌ryanodine受体(RyR1)的效应
  • 作为Ca2+传感器钙调蛋白(CaM)的抑制剂
  • 作为圆二色性(CD)光谱的标准品,以确定脂肽各种相互作用的脂质选择性

生化/生理作用

Lyso SM(d18:1)或鞘氨醇磷酸胆碱(SPC)是一种脂质介体,具有第二信使功能。它调节ryanodine受体(RyRs),并从肌浆网/内质网释放Ca2+。Lyso SM(d18:1)充当普遍存在的Ca2+传感器钙调蛋白(CaM)的内源性抑制剂。

包裝

5 mL棕色玻璃螺旋盖小瓶(860600P-10mg)
5 mL棕色玻璃螺旋盖小瓶(860600P-25mg)
5 mL棕色玻璃螺旋盖小瓶(860600P-50mg)
5 mL棕色玻璃螺旋盖小瓶(860600P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Dagmar Meyer zu Heringdorf et al.
Biochimica et biophysica acta, 1582(1-3), 178-189 (2002-06-19)
Compared to the lysophospholipid mediators, sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), little information is available regarding the molecular mechanisms of action, metabolism and physiological significance of the related sphingosylphosphorylcholine (SPC). S1P and LPA have recently been established as agonists at
Erika Kovacs et al.
Biochemical and biophysical research communications, 401(2), 281-286 (2010-09-21)
Sphingosylphosphorylcholine (SPC), a lipid mediator with putative second messenger functions, has been reported to regulate ryanodine receptors (RyRs), Ca2+ channels of the sarco/endoplasmic reticulum. RyRs are also regulated by the ubiquitous Ca2+ sensor calmodulin (CaM), and we have previously shown
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
The Journal of biological chemistry, 280(52), 43280-43280 (2006-02-25)
Tomokazu Yasuda et al.
Langmuir : the ACS journal of surfaces and colloids, 34(44), 13426-13437 (2018-10-24)
In this study, we applied fluorescence spectroscopy, differential scanning calorimetry (DSC), and 2H NMR to elucidate the properties of nanoscopic segregated domains in stearoylsphingomyelin (SSM)/dioleoylphosphatidylcholine (DOPC) and dihydrostearoylsphingomyelin (dhSSM)/DOPC binary membranes. The results obtained from fluorescence measurements suggest the existence
Caius G Radu et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(1), 245-250 (2003-12-19)
G2A is an immunoregulatory G protein-coupled receptor predominantly expressed in lymphocytes and macrophages. Ectopic overexpression studies have implicated G2A as a receptor for the bioactive lysophospholipid, lysophosphatidylcholine (LPC). However, the functional consequences of LPC-G2A interaction at physiological levels of receptor

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门