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Merck
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文件

850186P

Avanti

08:0 PI(3,4,5)P3

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium salt), powder

别名:

PIP3[3′,4′,5′](8:0/8:0); 110667

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About This Item

经验公式（希尔记法）:
C25H62N4O22P4
CAS号:
852043-38-0
分子量:
894.67
分類程式碼代碼:
51191904
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 100 μg (with stopper and crimp cap (850186P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850186P-500ug))

製造商／商標名

Avanti Research™ - A Croda Brand 850186P

脂質類型

phospholipids
cardiolipins

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1O)([O-])=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+].[NH4+]

相关类别

一般說明

磷脂酰肌醇3，4，5-三磷酸（PI（3，4，5）P3）是一种不太丰富的脂质。
肌醇磷脂物质是膜结合的信号分子，它参与细胞生理学的几乎所有方面，包括细胞生长、代谢、增殖和存活。

應用

08:0 PI（3，4，5）P3可用作评估磷酸肌醇3-激酶活性的对照化合物。

生化／生理作用

磷脂酰肌醇3，4，5-三磷酸（PI（3，4，5）P3），脂质第二信使可以调节突触活性。

包裝

带塞子和压接盖的2 mL棕色血清瓶（850186P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850186P-500ug）

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

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Thang Manh Khuong et al.
Neuron, 77(6), 1097-1108 (2013-03-26)
PI(3,4,5)P3 is a low-abundance lipid thought to play a role in the regulation of synaptic activity; however, the mechanism remains obscure. We have constructed novel split Venus-based probes and used superresolution imaging to localize PI(3,4,5)P3 at Drosophila larval neuromuscular synapses. We find
Rays H Y Jiang et al.
Cell host & microbe, 11(2), 99-100 (2012-02-22)
Survival of blood stage malaria parasites requires extensive host cell remodeling, which is facilitated by secretion of parasite proteins via a dedicated protein export pathway. In a recent Cell paper, Bhattacharjee et al., (2012) describe PI(3)P binding as one of the
Sulochanadevi Baskaran et al.
Molecular cell, 47(3), 339-348 (2012-06-19)
Macroautophagy is essential to cell survival during starvation and proceeds by the growth of a double-membraned phagophore, which engulfs cytosol and other substrates. The synthesis and recognition of the lipid phosphatidylinositol 3-phosphate, PI(3)P, is essential for autophagy. The key autophagic
Gerald R V Hammond et al.
Science (New York, N.Y.), 337(6095), 727-730 (2012-06-23)
The quantitatively minor phospholipid phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P(2)] fulfills many cellular functions in the plasma membrane (PM), whereas its synthetic precursor, phosphatidylinositol 4-phosphate (PI4P), has no assigned PM roles apart from PI(4,5)P(2) synthesis. We used a combination of pharmacological and chemical

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