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850166P

Avanti

18:0-20:4 PI(3,4,5)P3

1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium salt), powder

别名:

1-十八烷酰基-2-（5Z,8Z,11Z,14Z-二十碳四烯酰基）-sn-甘油-3-[磷酸肌醇-3,4,5-三磷酸]（铵盐）；PIP3[3′,4′,5′](18:0/20:4(5Z,8Z,11Z,14Z))

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About This Item

经验公式（希尔记法）:
C47H98N4O22P4
CAS号:
799268-60-3
分子量:
1195.19
分類程式碼代碼:
51191904
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 100 μg (with stopper and crimp cap (850166P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850166P-500ug))

製造商／商標名

Avanti Research™ - A Croda Brand 850166P

脂質類型

phospholipids
cardiolipins

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1O)([O-])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+].[NH4+]

InChI

1S/C47H86O22P4.4H3N/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)65-39(37-63-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-64-73(61,62)69-44-42(50)45(66-70(52,53)54)47(68-72(58,59)60)46(43(44)51)67-71(55,56)57;;;;/h11,13,17,19,22,2

InChI 密鑰

HIQNCTCJCORHBS-KVPNKVSCSA-N

相关类别

一般說明

肌醇磷脂物质是膜结合的信号分子，它参与细胞生理学的几乎所有方面，包括细胞生长、代谢、增殖和存活。

應用

18:0-20:4 PI（3，4，5）P3或1-硬脂酰基-2-花生四烯酰基-sn-甘油-3-磷酸-（1′-myo-肌醇-3′,4′,5′-三磷酸）（铵盐）已用于：
  • 脂质体沉淀测定的脂质体，以鉴定FCH和双SH3域蛋白（FCHSD2）对特定磷酸肌醇脂质体的结合偏好
  • 研究特定的蛋白质-脂质相互作用的脂质体
  • 宿主1-O-1-（Z）-十八碳烯基-2-花生四烯酰基-sn-甘油-3-磷酸胆碱（plasmenyl-SAPC）小单层囊泡（SUVs），在H2O2存在下，激活cyt c缩醛磷脂酶活性

包裝

带塞子和压接盖的2 mL棕色血清瓶（850166P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850166P-500ug）

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

历史批次信息供参考:

分析证书(COA)

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Christopher M Jenkins et al.
The Journal of biological chemistry, 293(22), 8693-8709 (2018-03-14)
Plasmalogens are phospholipids critical for cell function and signaling that contain a vinyl ether linkage at the sn-1 position and are highly enriched in arachidonic acid (AA) at the sn-2 position. However, the enzyme(s) responsible for the cleavage of the
Nicola De Franceschi et al.
Journal of cell science, 132(4) (2018-08-04)
Integrin transmembrane receptors control a wide range of biological interactions by triggering the assembly of large multiprotein complexes at their cytoplasmic interface. Diverse methods have been used to investigate interactions between integrins and intracellular proteins, and predominantly include peptide-based pulldowns
Leonardo Almeida-Souza et al.
Cell, 174(2), 325-337 (2018-06-12)
Multiple proteins act co-operatively in mammalian clathrin-mediated endocytosis (CME) to generate endocytic vesicles from the plasma membrane. The principles controlling the activation and organization of the actin cytoskeleton during mammalian CME are, however, not fully understood. Here, we show that

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