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Merck

840030C

Avanti

06:0 PS

1,2-dihexanoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform

别名:

PS(6:0/6:0)

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About This Item

经验公式(希尔记法):
C18H33NO10PNa
分子量:
477.42
分類程式碼代碼:
51191904
NACRES:
NA.25

化驗

>99% (TLC)

形狀

liquid

包裝

pkg of 1 × 1 mL (840030C-10mg)
pkg of 1 × 2.5 mL (840030C-25mg)

製造商/商標名

Avanti Polar Lipids 840030C

濃度

10 mg/mL (840030C-10mg)
10 mg/mL (840030C-25mg)

脂質類型

phospholipids
cardiolipins

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCC)=O)COC(CCCCC)=O.[Na+]

InChI

1S/C18H34NO10P.Na/c1-3-5-7-9-16(20)26-11-14(29-17(21)10-8-6-4-2)12-27-30(24,25)28-13-15(19)18(22)23;/h14-15H,3-13,19H2,1-2H3,(H,22,23)(H,24,25);/q;+1/p-1/t14-,15+;/m1./s1

InChI 密鑰

OPDYVXCKOQKYDZ-LIOBNPLQSA-M

一般說明

Phosphoserine/phosphatidylserine (PS) is an endogenous phospholipid, that is found in all polyanionic macromolecules like bone, enamel and dentin.

應用

06:0 PS may be used:
  • to study its effect on α-syn (α-synuclein) oligomerization by DA (dopamine)
  • to prepare phosphatidylserine (PS) liposomes
  • as a phospholipid substrate to determine the kinetic parameters for phospholipase C by chromogenic assay

生化/生理作用

Phosphoserine (PS) can be used as a template moiety for the recognition of cancer antigen 125 (CA 125). It is essential for healthy nerve cell membranes and myelin. Exogenous PS can be actively absorbed in humans and is blood-brain barrier traversable. PS actively participates in the locomotor functions.

包裝

5 mL Clear Glass Sealed Ampule (840030C-10mg)
5 mL Clear Glass Sealed Ampule (840030C-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

does not flash

閃點(°C)

does not flash


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Athena Sudom et al.
The Journal of biological chemistry, 293(32), 12634-12646 (2018-05-26)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's disease (AD), and the molecular
Chi L L Pham et al.
Bioscience reports, 33(5) (2013-09-27)
The deposition of α-syn (α-synuclein) as amyloid fibrils and the selective loss of DA (dopamine) containing neurons in the substantia nigra are two key features of PD (Parkinson's disease). α-syn is a natively unfolded protein and adopts an α-helical conformation
Peter A Leventis et al.
Annual review of biophysics, 39, 407-427 (2010-03-03)
Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly

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