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Merck
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Key Documents

810180C

Avanti

TopFluor™ TMR PC

Avanti Research™ - A Croda Brand 810180C

别名:

1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine

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About This Item

经验公式（希尔记法）:
C53H82 BF2N4 O10P
CAS号:
2260795-27-3
分子量:
1015.02
分類程式碼代碼:
12352211
NACRES:
NA.25

化驗

>99% (TLC)

形狀

liquid

包裝

pkg of 1 × 1 mL (810180C-1mg)

製造商／商標名

Avanti Research™ - A Croda Brand 810180C

濃度

1 mg/mL (810180C-1mg)

運輸包裝

dry ice

儲存溫度

−20°C

相关类别

一般說明

Tetramethylrhodamine (TMR) phosphatidylcholine (PC) is an acyl-chain-modified fluorescently labeled phospholipid. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotes and a prime metabolite of glycerolipid metabolism.

應用

TopFluor™ TMR PC or 1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine has been used to label biotinylated giant plasma membrane vesicles (GPMV). It is also suitable for the formation of lipid membranes in microarrays.

生化／生理作用

TopFluor™-labeled lipids have spectral properties similar to tetramethylrhodamine (TMR).

包裝

5 mL Amber Glass Screw Cap Vial (810180C-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

標靶器官

Central nervous system, Liver,Kidney

水污染物質分類（WGK）

WGK 3

分析证书(COA)

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Single-molecule analysis of phospholipid scrambling by TMEM16F
Rikiya W, et al.
Proceedings of the National Academy of Sciences of the USA, 115(12), 3066-3071 (2018)
Rikiya Watanabe et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(12), 3066-3071 (2018-03-07)
Transmembrane protein 16F (TMEM16F) is a Ca2+-dependent phospholipid scramblase that translocates phospholipids bidirectionally between the leaflets of the plasma membrane. Phospholipid scrambling of TMEM16F causes exposure of phosphatidylserine in activated platelets to induce blood clotting and in differentiated osteoblasts to
Libing Mu et al.
Nature communications, 9(1), 4259-4259 (2018-10-17)
Phagocytosis is one of the earliest cellular functions, developing approximately 2 billion years ago. Although FcR-based phagocytic signaling is well-studied, how it originated from ancient phagocytosis is unknown. Lipid redistribution upregulates a phagocytic program recapitulating FcR-based phagocytosis with complete dependence

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