QBD10760

t-Boc-N-amido-dPEG^®₈-acid

>95% (HPLC)

• 别名: t-Boc-N-amido-PEG₈-COOH, t-Boc-N-amido-PEG₈-acid, t-Boc-PEG-acid, BocNH-​PEG₈-​CH₂CH₂COOH
• 经验公式（希尔记法）: C₂₄H₄₇NO₁₂
• 分子量: 541.63
• MDL號碼: MFCD13185254
• 分類程式碼代碼: 12352106
• NACRES: NA.22

属性

• 化驗: >95% (HPLC)
• 形狀: solid or viscous liquid
• 反應適用性: reaction type: Pegylations
• 聚合物結構: shape: linear; functionality: heterobifunctional
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

特點和優勢

t-Boc-N-amido-dPEG₈-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atoms-long dPEG spacer allows the introduction of a short, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEG_n-acid (n=4, 8, 12, 24, 36) product series.

法律資訊

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable