QBD10551

MAL-dPEG^®₄-TFP ester

• 别名: Polyethylene glycol
• 经验公式（希尔记法）: C₂₄H₂₈F₄N₂O₉
• 分子量: 564.48
• MDL號碼: MFCD28505515
• 分類程式碼代碼: 12352108
• PubChem物質ID: 329823940
• NACRES: NA.22

属性

• 化驗: >90%
• 形狀: solid or viscous liquid
• 反應適用性: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• 官能基: ester; maleimide
• 聚合物結構: shape: linear; functionality: heterobifunctional
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: O=C(NCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O)CCN2C(C=CC2=O)=O
• InChI: 1S/C24H28F4N2O9/c25-16-15-17(26)23(28)24(22(16)27)39-21(34)4-7-35-9-11-37-13-14-38-12-10-36-8-5-29-18(31)3-6-30-19(32)1-2-20(30)33/h1-2,15H,3-14H2,(H,29,31)
• InChI 密鑰: LKZRDWRFDOPKGN-UHFFFAOYSA-N

说明

特點和優勢

MAL-dPEG^®₄-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG^® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

法律資訊

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable