儲存溫度
2-8°C
品質等級
一般說明
QTPD Amine set comprised of 36 partial protacs plated in duplicate with rich linker diversity, architecture and length targeting Cereblon(CRBN) and von Hippel Lindau( VHL) E3 ligases ending in a amine terminal.
應用
This set can be used for reacting with warheads/ligands for targets of interest with solvent exposed pendant carboxylic acid handles via peptide coupling reactions. Two distinct warheads can be reacted with this set to generate 72 distinct small molecule degraders that can be used for subsequent screening.
特點和優勢
Representative set of partial protacs targeting both CRBN and VHL with typical PEG, hydrophobic and rigid linkers that can be used for construction of PROTACs. Customers can make screen upto 24 reaction conditions with this set and empty glass shell vials provided with the pre-plated set. Glass shell vials allow for exploration of reaction conditions tolerant to different, reagents, solvents and temperature. Miniaturized synthesis allows for reduction in solvent, reagent, water and energy usage making this a sustainable and faster route to PROTAC discovery.
其他說明
QuicTPD Amine Screening Set
訊號詞
Warning
危險分類
Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2
標靶器官
Blood
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
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