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Merck

P1101

Sigma-Aldrich

D-青霉胺二硫化物

97%, cell analysis

别名:

3,3′-二硫代双(2-氨基-3-甲基丁酸), S,S′-二(D-青霉胺), 二硫青霉胺

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About This Item

线性分子式:
[-SC(CH3)2CH(NH2)CO2H]2
CAS号:
分子量:
296.41
Beilstein:
4461521
EC號碼:
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.22

product name

D-青霉胺二硫化物, 97%

化驗

97%

形狀

powder or crystals

光學活性

[α]25/D −75°, c = 1 in 1 M NaOH

反應適用性

reaction type: solution phase peptide synthesis

顏色

white

mp

204 °C (dec.) (lit.)

應用

cell analysis

SMILES 字串

CC(C)(SSC(C)(C)[C@@H](N)C(O)=O)[C@@H](N)C(O)=O

InChI

1S/C10H20N2O4S2/c1-9(2,5(11)7(13)14)17-18-10(3,4)6(12)8(15)16/h5-6H,11-12H2,1-4H3,(H,13,14)(H,15,16)/t5-,6-/m0/s1

InChI 密鑰

POYPKGFSZHXASD-WDSKDSINSA-N

應用

Used in pharmacological studies of:
  • Molecules dermatomyositis activity
  • Antimelanoma activity of apoptogenic carbonyl scavengers

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Y J Yang et al.
Occupational and environmental medicine, 51(4), 267-270 (1994-04-01)
Four workers chronically exposed to elemental mental mercury in a lampsocket manufacturing factory were studied. The clinical manifestations were severe in one, mild in another, and suspicious in the remaining two. Correlation between severity of clinical features and increased urinary
Quantification of pipecolic acid in plasma, and of urinary cystine in the presence of penicillamine-cystine disulfide, with the Beckman 6300 amino acid analyzer.
J Wong et al.
Clinical chemistry, 33(7), 1302-1303 (1987-07-01)
G Carruthers et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 7(1), 35-40 (1984-01-01)
The pharmacokinetic disposition of D-penicillamine and its major metabolites, penicillamine cysteine disulfide ( PSSC ) and penicillamine disulfide ( PSSP ) has been studied in eight patients with rheumatoid arthritis. Plasma concentrations of D-penicillamine, PSSP and PSSC displayed similar characteristics
F Matthey et al.
Clinical nephrology, 25(5), 268-271 (1986-05-01)
D-penicillamine and its major metabolites cysteine-penicillamine disulphide (CP) and penicillamine disulphide (P2) concentrations were measured in plasma from a hemodialysis patient with rheumatoid arthritis. CP and P2 alone were measured in plasma and a plasma ultrafiltrate from a second patient.
J K Nicholson et al.
Drug metabolism and drug interactions, 6(3-4), 439-446 (1988-01-01)
Preliminary studies on the use of high resolution 1H-NMR spectroscopy for the detection of the thiol drug penicillamine and its metabolites in human urine are described. The technique is rapid, simple and requires minimal sample pretreatment. Application of NMR to

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