936588

(S,R,S)-AHPC-acetamido-O-PEG2-C1-acid

≥95%

• 别名: (4R)-N-[2-[2-[2-(Carboxymethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, (S)-13-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-ylcarbonyl]-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecanoic acid, (S)-13-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidine-1-carbonyl]-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecanoic acid, L-Prolinamide, N-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• 经验公式（希尔记法）: C₃₀H₄₂N₄O₉S
• CAS号: 2172820-10-7
• 分子量: 634.74
• MDL號碼: MFCD33020891
• 分類程式碼代碼: 12352106
• NACRES: NA.22

属性

• ligand: VH032
• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder or crystals
• 顏色: white to beige
• 儲存溫度: 2-8°C
• SMILES 字串: C([C@@H](NC(COCCOCCOCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

说明

應用

(S,R,S)-AHPC-acetamido-O-PEG2-C1-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

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Protein Degrader Building Blocks

其他說明

Targeted Protein Degradation by Small Molecules


Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG


Small-Molecule PROTACS: New Approaches to Protein Degradation


Targeted Protein Degradation: from Chemical Biology to Drug Discovery


Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable