926248

Redox Responsive Poly(ethylene glycol)-block-poly(lactide-alt-glycolide)

PEG average M_n 5000, PLGA M_n 15000

• 别名: Drug release, PEG-PLGA with disulfide linkage, PEG-SS-PLGA, Stimuli-responsive
• 线性分子式: CH₃O(C₂H₄O)_nC₇H₁₂O₄S₂(C₅H₆O₄)_m
• 分類程式碼代碼: 12352112
• NACRES: NA.23

属性

• 形狀: powder, chunks or granules
• 品質等級: 100
• 分子量: PEG average M_n 5000; PLGA M_n 15000
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(C(C)OC(CO[H])=O)OCCSSCCOC(OCCOCCOC)=O

说明

應用

PEG-SS-PLGA is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(lactide-alternative-glycolide) (PLGA) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.

Different from common Poly(lactide-co-glycolide) (PLGA) polymer, the lactic and glycolic units in Poly(lactide-alt-glycolide) block alternate in sequence in the polymer chain, and the molar ratio of lactic to glycolic units in the polymer is exactly 1:1.

Poly(lactide-alt-glycolide) exhibits excellent solubility in common organic solvents, such as acetonitrile, acetone, dioxane, DCM, and THF, providing great convenience for drug delivery researches and applications.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable