91862

三甲基（三氟甲基）硅烷 溶液

2 M in THF

• 别名: (Trifluoromethyl)trimethylsilane, TFMTMS
• 线性分子式: (CH₃)₃SiCF₃
• CAS号: 81290-20-2
• 分子量: 142.19
• Beilstein: 4241868
• MDL號碼: MFCD00145454
• 分類程式碼代碼: 12352101
• PubChem物質ID: 57653455
• NACRES: NA.22

属性

• 形狀: liquid
• 品質等級: 100
• 反應適用性: reaction type: C-C Bond Formation
• IVD: for in vitro diagnostic use
• 濃度: 2 M in THF
• 折射率: n20/D 1.386
• 密度: 0.91 g/mL at 20 °C
• 官能基: fluoro
• SMILES 字串: C[Si](C)(C)C(F)(F)F
• InChI: 1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
• InChI 密鑰: MWKJTNBSKNUMFN-UHFFFAOYSA-N

说明

一般說明

Trimethyl(trifluoromethyl)silane (TMSCF₃) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.

應用

Reactant for:

• Silver-mediated C-H trifluoromethylation of arenes
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
• Palladium-catalyzed oxidative trifluoromethylation of indoles
• Preparation of 5-HT1A antagonists

• Used as difluorocarbene source

TMSCF₃ can be used as a reagent for:

• Conversion of aromatic aldehydes to difluoromethylated products.
• C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.

It can also be used in trifluoromethylation of:

• Non-activated aldimines.
• Heterocumulenes.
• Azomethine imines.

安全信息

• 象形圖: GHS02,GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H225,H302,H319,H335,H351
• 防範說明: P210 - P280 - P301 + P312 + P330 - P305 + P351 + P338 - P370 + P378 - P403 + P235
• 危險分類: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 安全危害: EUH019
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 1.4 °F
• 閃點（°C）: -17 °C
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter