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描述
Methacrylated collagen:
Degree of methacrylation ≥ 20%
Product components :
Methacrylated collagen (100 mg)
20 mM acetic acid (50 mL)
Neutralization solution (10 mL)
Ruthenium (100 mg)
Sodium persulfate photoinitiator (500 mg)
品質等級
無菌
sterile; sterile-filtered
雜質
≤10 EU/mL Endotoxin
儲存溫度
2-8°C
應用
PhotoCol™-RUT bioink kit consists of purified methacrylated Type I bovine collagen as the core component with other support reagents. The methacrylated Type I collagen is produced from telo-peptide intact bovine collagen where the collagen has been modified by reacting the free amines, primarily the ε-amines groups of the lysine residues as well as the α-amines groups on the N-termini. Over 20% of the total lysine residues of the collagen molecule have been methacrylated. A bottle of 20 mM acetic acid solution is provided to solubilize the lyophilized methacrylated collagen at concentrations ranging from 3 to 8 mg/ml. The neutralization solution consists of an alkaline 10X phosphate buffered saline (PBS) solution which provides physiological salts and pH in the final mixture. The photoinitiator consists of ruthenium and sodium persulfate to be formulated in 1X cell culture media or PBS, which allows visible light photocrosslinking of the printed structure at 400-450 nm. PhotoCol™-RUT provides native-like 3D collagen gels, and the final gel stiffness can be customized by changing collagen concentrations and crosslinking.
法律資訊
PhotoCol is a trademark of Advanced BioMatrix, Inc.
Ian D Gaudet et al.
Biointerphases, 7(1-4), 25-25 (2012-05-17)
Type-I collagen is an attractive scaffold material for tissue engineering due to its ability to self-assemble into a fibrillar hydrogel, its innate support of tissue cells through bioactive adhesion sites, and its biodegradability. However, a lack of control of material
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The current drug development pipeline takes approximately fifteen years and $2.6 billion to get a new drug to market. Typically, drugs are tested on two-dimensional (2D) cell cultures and animal models to estimate their efficacy before reaching human trials. However
Andrea Mazzocchi et al.
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Lung cancer is the leading cause of cancer-related death worldwide yet in vitro disease models have been limited to traditional 2D culture utilizing cancer cell lines. In contrast, recently developed 3D models (organoids) have been adopted by researchers to improve
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