909661

d0-DMDSSO crosslinker

≥95%

• 别名: Bis(2,5-dioxopyrrolidin-1-yl) 3,3′-sulfinylbis(2-methylpropanoate), Mass spectrometry-cleavable crosslinker for studying protein-protein interactions
• 经验公式（希尔记法）: C₁₆H₂₀N₂O₉S
• CAS号: 1554583-88-8
• 分子量: 416.40
• 分類程式碼代碼: 12352106

属性

• 化驗: ≥95%
• 形狀: powder
• 儲存溫度: 2-8°C

说明

應用

d0-DMDSSO (dimethyl-disuccinimidyl sulfoxide) crosslinker is a homobifunctional, lysine residue-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). d0-DMDSSO possesses two N-hydroxysuccinimide (NHS) ester groups for targeting amines and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. The post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS. d0-DMDSSO crosslinker will also be a useful proteomics tool and aid in the quest for targeting ″undruggable″ protein targets.

其他說明

Technology Spotlight: Cross-Linkers for Elucidation of Protein-Protein Interactions

Developing New Isotope-Coded Mass Spectrometry-Cleavable Cross-Linkers for Elucidating Protein Structures

法律資訊

Subject to US Patent Application #15/275,001 of the Regents of the University of California

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable