901708

Thiol-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average M_n 5000, PCL average M_n 5000

• 线性分子式: C₅H₁₀S₂O[C₂H₄O]n[C₆H₁₀O₂]mH
• 分類程式碼代碼: 51171641
• NACRES: NA.23

属性

• 形狀: powder or solid
• 分子量: PCL average M_n 5000; PEG average M_n 5000
• 顏色: white to off-white
• 蛋白質二硫鍵異構酶: ≤1.3 (By GPC)
• 儲存溫度: −20°C

说明

應用

Thiol-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The thiol functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P301 + P312 + P330
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable