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39915

Sigma-Aldrich

七(2,6-二-O-甲基)-β-环糊精

≥98.0% (TLC)

别名:

2,6-二-O-甲基-β-环糊精, 二甲基 β-环糊精

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About This Item

经验公式（希尔记法）:
C56H98O35
CAS号:
51166-71-3
分子量:
1331.36
Beilstein:
1679144
MDL號碼:
MFCD00011616
分類程式碼代碼:
12352005
PubChem物質ID:
57649911
NACRES:
NA.22

化驗

≥98.0% (TLC)

光學活性

[α]20/D +158±3°, c = 10% in H2O

雜質

≤3% water

SMILES 字串

COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](OC)[C@H](O[C@@H]3COC)O[C@H]4[C@H](O)[C@@H](OC)[C@H](O[C@@H]4COC)O[C@H]5[C@H](O)[C@@H](OC)[C@H](O[C@@H]5COC)O[C@H]6[C@H](O)[C@@H](OC)[C@H](O[C@@H]6COC)O[C@H]7[C@H](O)[C@@H](OC)[C@H](O[C@@H]7COC)O[C@H]8[C@H](O)[C@@H](OC)[C@H](O[C@@H]8COC)O[C@H]1[C@H](O)[C@H]2OC

InChI

1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3/t22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-/m1/s1

InChI 密鑰

QGKBSGBYSPTPKJ-UZMKXNTCSA-N

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一般說明

Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a water-soluble derivative of cyclodextrin that exhibits the ability to effectively dissolve lipophilic drugs like steroid hormones, vitamins A, E, and K, etc. It can be used to improve the solubility and bioavailability of weakly hydrophilic pharmaceutical compounds.

應用

涉及的反应物：
  • 包合物的理化研究
  • 与重组膜蛋白的探测扩散和单分子相互作用
  • 与胶束的相互作用导致胶束破裂
  • 研究细胞转运，用作细胞渗透促进剂
  • 药物的理化和生物药剂学改进 ，特别是溶解和稳定性
  • 与胆固醇的相互作用
Heptakis(2,6-di-O-methyl)-β-cyclodextrin may be used:
  • To measure the equilibrium constant of its complexes with various enantiomeric pairs of chiral nitroxides by electron paramagnetic resonance (EPR) spectroscopy.
  • To study the crystal structure of its complex with n-butyl acrylate and isobornyl acrylate using X-ray diffraction (XRD).
  • As a chiral selector to resolve amphetamine related drugs and reduced haloperidol by capillary zone electrophoresis.
  • As a component of thermosensitive polyurethane copolymers for their subsequent analysis by gel permeation chromatography (GPC).

其他說明

复合物比相应的 β-环糊精复合物具有更高的水溶性；刺激脂肪酸的合成

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCF6846
BCCF6041
BCCC7427
BCCB8810
BCBZ8457

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B. Casu et al.
Carbohydrate Research, 76, 59-59 (1979)
Effects of cyclodextrins on fatty acid synthesis.
Y Machida et al.
The Journal of biological chemistry, 248(17), 6246-6247 (1973-09-10)
New thermogelling copolymers composed of heptakis (2, 6-di-O-methyl)-beta-cyclodextrin, poly (propylene glycol), and poly (ethylene glycol)
Yang C, et al.
Journal of Materials Chemistry, 19(22), 3755-3763 (2009)
Michelle Amoako-Tuffour et al.
Acta pharmaceutica (Zagreb, Croatia), 59(4), 395-405 (2009-11-19)
The potential for nasal delivery of losartan, a drug with poor oral bioavailability, was investigated using Calu-3 cells. Epithelial permeation of the drug with or without dimethyl-beta-cyclodextrin (DM-beta-CD) and glycocholate was investigated. Possible transport mechanism of the compound and epithelial
Kanokthip Boonyarattanakalin et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 752-758 (2012-08-28)
The inclusion complexes of highly potent anti-HIV agent, UC781, with β-cyclodextrin (βCD), 2,6-dimethyl-β-cyclodextrin (MβCD), and 2-hydroxypropyl-β-cyclodextrin (HPβCD) in aqueous solution were investigated by molecular dynamics simulations. Simulations show that the phenyl ring of UC781 is trapped inside CD cavities, while
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