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Merck

361518

Sigma-Aldrich

1-羟基芘

98%

别名:

1-Pyrenol

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About This Item

经验公式(希尔记法):
C16H10O
CAS号:
分子量:
218.25
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

98%

mp

179-182 °C (lit.)

SMILES 字串

Oc1ccc2ccc3cccc4ccc1c2c34

InChI

1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H

InChI 密鑰

BIJNHUAPTJVVNQ-UHFFFAOYSA-N

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一般說明

1-羟基芘作为尿液代谢产物,是多环芳烃 (PAH) 暴露的标志物。1-羟基芘是暴露于芘的重要生物标志物。

應用

1-羟基芘适用于以下研究:
  • 探讨用简单的荧光法快速检测和定量测定暴露于沉积物相关芘的杂色沙蚕组织提取液中的 1-羟基芘。
  • 探讨细胞色素 P450 1A1 (CYP1A1) 和 2E1 (CYP2E1) 以及谷胱甘肽 S-转移酶 mu (GSTM1) 和 θ (GSTT1) 的基因多态性对飞机维修工人尿 1-羟基芘和 2-萘酚水平的影响。
  • 研究爱沙尼亚油页岩加工厂焦化厂工人的多环芳烃暴露情况。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Anders M B Giessing et al.
Marine environmental research, 56(5), 599-615 (2003-08-21)
The uptake of polycyclic aromatic hydrocarbons (PAHs) by marine deposit-feeding invertebrates can be determined by screening for PAH-derived metabolites. We identified 1-hydroxypyrene as the only intermediate metabolite in tissue of four species of deposit-feeding polychaetes, Nereis diversicolor, Nereis virens, Arenicola
F J Jongeneelen
Toxicology letters, 72(1-3), 205-211 (1994-06-01)
A biomarker of human exposure to chemical agents provides a valuable parameter for assessing the extent and significance of the uptake by giving a measurement that is direct and integrated over time and exposure routes. Urinary 1-hydroxypyrene is currently tested
Christiana A Demetriou et al.
Occupational and environmental medicine, 69(9), 619-627 (2012-07-10)
The association between ambient air pollution exposure and lung cancer risk has been investigated in prospective studies and the results are generally consistent, indicating that long-term exposure to air pollution may cause lung cancer. Despite the prospective nature and consistent
Laura Campo et al.
International journal of environmental research and public health, 15(6) (2018-06-06)
Active smoking is associated with increased body burden of polycyclic aromatic hydrocarbons (PAHs); the aim of this study was to assess whether environmental tobacco smoking (ETS) increases the internal dose of PAHs. In 344 nonsmoking Italian adults, out of 497
Ase M Hansen et al.
International journal of hygiene and environmental health, 211(5-6), 471-503 (2008-01-29)
A total of 132 studies were identified, of which 25 studies addressed environmental exposure to polycyclic aromatic hydrocarbons (PAHs) in the general population. Of these 9 studies included children. Of 101 studies among workers in various occupations, 32 studies were

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