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Merck

335975

Sigma-Aldrich

氯甲酸(+)-1-(9-芴)乙酯 溶液

18 mM in acetone, for chiral derivatization

别名:

(+)-FLEC 溶液

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About This Item

经验公式(希尔记法):
C16H13ClO2
分子量:
272.73
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.22

等級

for chiral derivatization

品質等級

蒸汽密度

2 (vs air)

蒸汽壓力

180 mmHg ( 20 °C)

形狀

liquid

濃度

18 mM in acetone

折射率

n20/D 1.3602

密度

0.79 g/mL at 25 °C

官能基

chloro

儲存溫度

2-8°C

InChI

1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3

InChI 密鑰

SFRVOKMRHPQYGE-UHFFFAOYSA-N

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一般說明

(+)-1-(9-芴基)乙基氯甲酸酯是高度荧光的化合物 1,通常用作手性衍生剂,用在进行反相 HPLC 分析之前分离外消旋体。

應用

  • β-甲基氨基丙氨酸(BMAA)对映体的手性分析:详细介绍了氯甲酸(+)-1--9-芴基乙酯(FLEC)的衍生化和随后的LC-MS/MS分析,增进了我们对氨基酸′立体化学的理解 (Zurita et al., 2019)。
  • DL-氨基酸的对映选择性胶束电动色谱:利用氯甲酸(+)-1--9-芴基乙酯进行衍生化,结合UV诱导的荧光检测进行氨基酸的分析,改善了分析方法(Prior et al., 2018)。

訊號詞

Danger

危險聲明

危險分類

Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

標靶器官

Central nervous system

安全危害

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

1.4 °F

閃點(°C)

-17 °C


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Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl) ethyl chloroformate.
Rosseel MT, et al.
Journal of Chromatography. B, Biomedical Applications, 568(1), 239-245 (1991)
E Frigerio et al.
Journal of chromatography. A, 660(1-2), 351-358 (1994-02-04)
A sensitive and selective high-performance liquid chromatographic method for the determination of reboxetine enantiomers in human plasma was developed. Although two chiral centres are present in reboxetine, its stereospecific synthesis leads to two rather than four possible enantiomers. After extraction
Y Bergqvist et al.
Journal of chromatography, 652(1), 73-81 (1994-01-14)
A sensitive, stereoselective and rapid reversed-phase liquid chromatographic method for the determination of (SR)- and (RS)-mefloquine enantiomers in 100 microliters plasma and capillary blood collected on chromatographic paper is presented. The assay involves protein precipitation from plasma, liquid-liquid extraction of
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1590, 80-87 (2019-01-15)
D-amino acids (AA) analysis is becoming more and more relevant for metabolomics, therefore new analytical tools need to be developed. A common approach to achieve AA enantioseparation is chiral derivatization. Among the chiral derivatization reagents, (+) or (-)-1-(9-fluorenyl) ethyl chloroformate
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1467, 400-408 (2016-08-25)
In the context of bioanalytical method development, process automatization is nowadays a necessity in order to save time, improve method reliability and reduce costs. For the first time, a fully automatized micellar electrokinetic chromatography-mass spectrometry (MEKC-MS) method with in-capillary derivatization

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