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Merck

308560

Sigma-Aldrich

4-氨基-6-氯-1,3-苯二磺酰胺

98%

别名:

5-氯-2,4-二磺酰胺基苯胺, 4-氨基-6-氯-1,3-苯二磺酰胺

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About This Item

线性分子式:
H2NC6H2(Cl)(SO2NH2)2
CAS号:
分子量:
285.73
Beilstein:
1083877
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

98%

形狀

powder

mp

257-261 °C (lit.)

SMILES 字串

Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O

InChI

1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)

InChI 密鑰

IHJCXVZDYSXXFT-UHFFFAOYSA-N

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一般說明

4-氨基-6-氯-1,3-苯二磺酰胺是胃病原体幽门螺杆菌(Helicobacter pylori ,hpCA)的有效抑制剂

應用

4-氨基-6-氯-1,3-苯二磺酰胺通过与适当标记的醛缩合,可用于合成氘代噻嗪类化合物

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Mario Thevis et al.
Analytical chemistry, 74(15), 3802-3808 (2002-08-15)
The mass spectrometric behavior of 21 thiazide-based compounds after electrospray ionization in the negative ion mode and collision-induced dissociation was investigated on a triple-stage quadrupole mass spectrometer. The mass spectra show individual and common fragmentation patterns, the generations of which
B R Thomas et al.
Journal of chromatography. B, Biomedical applications, 657(2), 383-394 (1994-07-15)
A stability-indicating, quality control analysis method was developed and validated for the diuretic drug substances hydrochlorothiazide (HCTZ) and chlorothiazide (CTZ). Micellar electrokinetic capillary chromatography employing the anionic detergent sodium dodecyl sulfate at 30 mM in 20 mM sodium borate buffer
Biopharmaceutical studies of thiazide diuretics. III. In vivo formation of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide in a patient.
T Okuda et al.
Chemical & pharmaceutical bulletin, 35(8), 3516-3518 (1987-08-01)
M Yamazaki et al.
Chemical & pharmaceutical bulletin, 38(10), 2882-2883 (1990-10-01)
2-Amino-4-chloro-m-benzenedisulfonamide (ACBS) is a metabolite of hydrochlorothiazide. We reported that the ACBS concentration in erythrocytes was higher than in plasma in a patient. Therefore the binding of ACBS to rabbit erythrocyte was studied. The Scatchard plot showed the nonlinear plot
K Deventer et al.
Journal of chromatography. A, 1216(12), 2466-2473 (2009-02-04)
In sports, thiazide diuretics are used to flush out previously taken prohibited substances with forced diuresis and in sports where weight classes are involved to achieve acute weight loss. Thiazide diuretics include compounds which are very unstable and hydrolyse in

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