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About This Item
线性分子式:
CH3(CH2)13CH(Br)CO2H
CAS号:
分子量:
335.32
Beilstein:
1726517
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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化驗
≥99.0% (GC)
形狀
solid
mp
52-54 °C
溶解度
methanol: soluble 1 g/10 mL, clear, colorless
chloroform: soluble
ethanol: soluble
water: insoluble
官能基
bromo
carboxylic acid
SMILES 字串
CCCCCCCCCCCCCCC(Br)C(O)=O
InChI
1S/C16H31BrO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(17)16(18)19/h15H,2-14H2,1H3,(H,18,19)
InChI 密鑰
DPRAYRYQQAXQPE-UHFFFAOYSA-N
基因資訊
human ... PPARD(5467)
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一般說明
2-Bromohexadecanoic acid, also known as 2-Bromopalmitic acid, is a long chain 2-haloalkanoic halogenated fatty acid that is commonly used as a building block in various organic reaction such as 2′-(2-bromohexadecanoyl)-docetaxel synthesis.
應用
<ul>
<li><strong>化学免疫疗法的应用：</strong>2-溴十六烷酸被用于制造生物活性脂肪酸类似物衍生的杂化纳米颗粒，用于癌症的化学免疫治疗，显示出在不需要抗体的情况下治疗癌症的潜力（Tan et al., 2023）。</li>
<li><strong>冠状病毒的药物靶点识别：</strong>2-溴棕榈酸酯（2-BP）可用作抑制SADS-CoV治疗的抑制剂（Luo et al., 2021）。</li>
<li><strong>癌症治疗的增强作用：</strong>该化合物可通过调节CHOP使骨肉瘤细胞对阿霉素诱导的细胞凋亡敏感，表明其在增强癌症治疗方面的潜力（Xu et al., 2019）。</li>
<li><strong>支持细胞的膜蛋白定位：</strong>它参与了与小鼠支持细胞微囊蛋白1结合将雄激素受体定位到质膜的相关研究，有助于揭示细胞信号通路。可用于抑制雄激素受体（AR）的棕榈酰化，并用于评估抑制剂对雄激素受体（AR）易位的影响（Deng et al., 2017）。</li>
<li><strong>棕榈酰化的抑制作用：</strong>2-溴十六烷酸被确定为棕榈酰化的不可逆抑制剂，为蛋白质修饰的调控及其在各种疾病中的影响提供了见解（Davda et al., 2013）。</li>
</ul>
<li><strong>化学免疫疗法的应用：</strong>2-溴十六烷酸被用于制造生物活性脂肪酸类似物衍生的杂化纳米颗粒，用于癌症的化学免疫治疗，显示出在不需要抗体的情况下治疗癌症的潜力（Tan et al., 2023）。</li>
<li><strong>冠状病毒的药物靶点识别：</strong>2-溴棕榈酸酯（2-BP）可用作抑制SADS-CoV治疗的抑制剂（Luo et al., 2021）。</li>
<li><strong>癌症治疗的增强作用：</strong>该化合物可通过调节CHOP使骨肉瘤细胞对阿霉素诱导的细胞凋亡敏感，表明其在增强癌症治疗方面的潜力（Xu et al., 2019）。</li>
<li><strong>支持细胞的膜蛋白定位：</strong>它参与了与小鼠支持细胞微囊蛋白1结合将雄激素受体定位到质膜的相关研究，有助于揭示细胞信号通路。可用于抑制雄激素受体（AR）的棕榈酰化，并用于评估抑制剂对雄激素受体（AR）易位的影响（Deng et al., 2017）。</li>
<li><strong>棕榈酰化的抑制作用：</strong>2-溴十六烷酸被确定为棕榈酰化的不可逆抑制剂，为蛋白质修饰的调控及其在各种疾病中的影响提供了见解（Davda et al., 2013）。</li>
</ul>
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
235.4 °F - closed cup
閃點（°C）
113 °C - closed cup
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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Chromatograms
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