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Merck

134910

Sigma-Aldrich

(1R,2S)-(-)-麻黄碱

98%

别名:

(-)-麻黄碱, (1R,2S)-(-)-α-(1-甲基氨基乙基)苄醇, (1R,2S)-(-)-2-甲氨基-1-苯丙醇, L-盐酸麻黄碱

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About This Item

线性分子式:
C6H5CH[CH(NHCH3)CH3]OH
CAS号:
分子量:
165.23
Beilstein:
2208730
EC號碼:
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

98%

形狀

solid

光學活性

[α]21/D −41°, c = 5 in 1 M HCl

bp

255 °C (lit.)

mp

37-39 °C (lit.)

密度

1.124 g/mL at 25 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

CN[C@@H](C)[C@H](O)c1ccccc1

InChI

1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1

InChI 密鑰

KWGRBVOPPLSCSI-WPRPVWTQSA-N

一般說明

(1R,2S)-(-)-Ephedrine, a chiral β-amino alcohol, is commonly used as a chiral auxiliary in asymmetric synthesis. It undergoes reduction to form (+)-methamphetamine.

應用

通用手性合成子,用于催化以及制备光学纯亚砜和噁唑烷。
(1R,2S)-(-)-Ephedrine can be used in the preparation of optically active phosphine-phosphonite ligands and chirally-substituted cyclopentadienyl (Cp) ligands. It reacts with phosphorus trichloride to form (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine. It can also act as a chiral resolving agent for (±)-mandelic acid.

象形圖

CorrosionExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類(WGK)

WGK 1

閃點(°F)

186.8 °F - closed cup

閃點(°C)

86 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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A L Carey et al.
Diabetologia, 56(1), 147-155 (2012-10-16)
Brown adipose tissue (BAT) activation increases energy consumption and may help in the treatment of obesity. Cold exposure is the main physiological stimulus for BAT thermogenesis and the sympathetic nervous system, which innervates BAT, is essential in this process. However
A novel nucleoside phosphoramidite synthon derived from 1R, 2S-ephedrine
Iyer RP, et al
Tetrahedron Asymmetry, 6(5), 1051-1054 (1995)
New chiral phosphine-phosphonites derived from (2R, 3R)-dimethyl tartrate,(S)-binaphthol and (1R, 2S)-ephedrine
Schull TL and Knight DA
Tetrahedron Asymmetry, 10(2), 207-211 (1999)
Investigation of (1R, 2S)-(-)-Ephedrine by Cryogenic Terahertz Spectroscopy and Solid-State Density Functional Theory.
Hakey PM, et al
ChemPhysChem, 10(14), 2434-2444 (2009)
Penelope P Howards et al.
PloS one, 7(11), e50372-e50372 (2012-11-21)
Medications may be consumed periconceptionally before a woman knows she is pregnant. In this study, the authors evaluate the association of a prescription diet drug (Letigen) containing ephedrine (20 mg) and caffeine (200 mg) with spontaneous abortion (SAB) in the

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