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Key Documents

SCP0139

Sigma-Aldrich

Caspase 8 Substrate, fluorogenic

≥95% (HPLC), lyophilized

Synonym(s):

Ac-VETD-AMC

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About This Item

Empirical Formula (Hill Notation):
C30H39N5O12
Molecular Weight:
661.66
UNSPSC Code:
12352202
NACRES:
NA.32

product name

Caspase 8 Substrate, fluorogenic,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥67%

storage condition

protect from light

storage temp.

−20°C

Gene Information

human ... CASP8(841)

Amino Acid Sequence

Ac-Val-Glu-Thr-Asp-AMC

Application

Fluorogenic caspase 8 substrate has been used to measure caspase 8 activity in Jurkat cell lysates.

Biochem/physiol Actions

The peptide Ac-Val-Glu-Thr-Asp-AMC, or Ac-VETD-AMC, is a fluorogenic, modified peptide substrate for caspase 8.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Functional intersection of Human Defensin 5 with the TNF receptor pathway
WuyuanLu Erikde Leeuw
Febs Letters, 558(10) (2014)
Apoptosis in polycystic kidney disease: involvement of caspases
Ali, S.M., et al.
The American Journal of Physiology, 278, R763-R769 (2000)
T L Yue et al.
The Journal of biological chemistry, 274(3), 1479-1486 (1999-01-09)
TL1 is a recently discovered novel member of the tumor necrosis factor (TNF) cytokine family. TL1 is abundantly expressed in endothelial cells, but its function is not known. The present study was undertaken to explore whether TL1 induces apoptosis in
Mikhail G Akimov et al.
Biomolecules, 10(2) (2020-02-16)
Cholines acylated with unsaturated fatty acids are a recently discovered family of endogenous lipids. However, the data on the biological activity of acylcholines remain very limited. We hypothesized that acylcholines containing residues of arachidonic (AA-CHOL), oleic (Ol-CHOL), linoleic (Ln-CHOL), and

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