C7505

L-Cystathionine

≥98% (TLC)

• Synonym(s): (R)-S-(2-Amino-2-carboxyethyl)-L-homocysteine
• Empirical Formula (Hill Notation): C₇H₁₄N₂O₄S
• CAS Number: 56-88-2
• Molecular Weight: 222.26
• Beilstein: 2505200
• EC Number: 200-295-8
• MDL number: MFCD00036685
• UNSPSC Code: 12352209
• PubChem Substance ID: 24892965
• NACRES: NA.26

Properties

• Quality Level: 200
• Assay: ≥98% (TLC)
• form: powder
• technique(s): UHPLC: suitable
• color: white
• mp: >300 °C
• storage temp.: −20°C
• SMILES string: N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
• InChI: 1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1
• InChI key: ILRYLPWNYFXEMH-WHFBIAKZSA-N

Description

Application

L-Cystathionine has been used in ultra-performance liquid chromatography for the validation of cystathionine and the correlation of its abundance with vertebrate metamorphosis. It has also been used as an inhibitor of sinusoidal GSH (glutathione) carrier to signify that thiol redox state imbalance is associated with the modulation of autophagy in carcinoma cells.

Biochem/physiol Actions

L-Cystathionine is an intermediate in the biosynthesis of L-cysteine and methionine. It is used as a substrate to differentiate and analyze cystathionine γ-lyase(s). L-Cystathionine is an important non-protein amino acid and is associated with metabolic disorders. In recent studies, L-cystathionine is believed to be the precursor of cyclic imino acid cyclothionine. Cystathioninuria is characterized with imino acid cyclothionine excretion in the urine.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves