M0252

Methylglyoxal solution

~40% in H₂O

• Synonym(s): Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde
• Linear Formula: CH₃COCHO
• CAS Number: 78-98-8
• Molecular Weight: 72.06
• Beilstein: 906750
• MDL number: MFCD00006960
• UNSPSC Code: 12352204
• PubChem Substance ID: 24896540
• NACRES: NA.32

Properties

• form: liquid
• concentration: ~40% (enzymatic); ~40% in H₂O
• density: 1.17 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: [H]C(=O)C(C)=O
• InChI: 1S/C3H4O2/c1-3(5)2-4/h2H,1H3
• InChI key: AIJULSRZWUXGPQ-UHFFFAOYSA-N

Description

General description

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.

Application

Methylglyoxal solution has been used:

• to assess glyoxalase 1 (GLO1) enzymatic activity
• as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro
• to regulate anxiety like behavior in mice
• to induce peritoneal fibrosis in rats
• to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts
• for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

Safety Information

• Pictograms: GHS08,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H290,H317,H318,H341
• Precautionary Statements: P202 - P234 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves