PZ0162

PD 0325901

≥98% (HPLC)

• Synonym(s): N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
• Empirical Formula (Hill Notation): C₁₆H₁₄F₃IN₂O₄
• CAS Number: 391210-10-9
• Molecular Weight: 482.19
• MDL number: MFCD08435926
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823743

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
• color: white to off-white
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC1=C(NC2=CC=C(I)C=C2F)C(C(NOC[C@H](O)CO)=O)=CC=C1F
• InChI: 1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
• InChI key: SUDAHWBOROXANE-SECBINFHSA-N
• Gene Information: human ... MAP2K1(5604) , MAP2K2(5605)

Description

Application

PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).

Biochem/physiol Actions

PD 0325901 by inhibiting mitogen-activated protein kinases (MAPKs) elicits growth-inhibitory and antiangiogenic effects on glioblastoma and melanoma tumor progression.

PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.

Features and Benefits

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301,H373,H413
• Precautionary Statements: P260 - P264 - P273 - P301 + P310 - P314 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4 - STOT RE 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable