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SML0443

Sigma-Aldrich

SU-5402

≥98% (HPLC), powder, FGFR inhibitor

Synonym(s):

3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid, PF-02969207, PNU-0290908

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About This Item

Empirical Formula (Hill Notation):
C17H16N2O3
CAS Number:
215543-92-3
Molecular Weight:
296.32
MDL number:
MFCD08235144
UNSPSC Code:
51111800
PubChem Substance ID:
329824725
NACRES:
NA.77

Product Name

SU-5402, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

light yellow to dark orange

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

−20°C

SMILES string

Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O

InChI

1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-

InChI key

JNDVEAXZWJIOKB-JYRVWZFOSA-N

Application

SU5402 has been used as a fibroblast growth factor receptor inhibitor:
  • in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay
  • to study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2
  • to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryos
  • to study its effect on osteogenic markers.

Biochem/physiol Actions

SU-5402 has inhibitory effect on the action of tyrosine kinases. It competitively binds to the ATP-binding site on the fibroblast growth factor receptor (FGFR).
SU-5402 is a FGFR antagonist and angiogenesis inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
126M4701V
125M4746V
104M4713V
014M4724V
103M4722V

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Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway
Yamashita T, et al.
The Journal of Biological Chemistry, 277(31), 28265-28270 (2002)
BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification
Liu X, et al.
Biochemical and Biophysical Research Communications, 503, 930-937 (2018)
Fibroblast growth factor 21 plays an inhibitory role in vascular calcification in vitro through OPG/RANKL system
Cao F, et al.
Biochemical and Biophysical Research Communications, 491(3), 578-586 (2017)
Fang Liang et al.
Scientific reports, 5, 14468-14468 (2015-10-09)
Natural products are a rich resource for the discovery of therapeutic substances. By directly using 504 fine fractions from isolated traditional Chinese medicine plants, we performed a transgenic zebrafish based screen for anti-angiogenesis substances. One fraction, DYVE-D3, was found to
Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures
Di LV, et al.
Biochim. Biophys. Acta Gen. Subj., 1861(2), 235-245 (2017)
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