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1672304

USP

Torsemide

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

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About This Item

Formule empirique (notation de Hill):
C16H20N4O3S
Numéro CAS:
56211-40-6
Poids moléculaire :
348.42
Numéro MDL:
MFCD00866166
Code UNSPSC :
41116107
ID de substance PubChem :
329751356
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

torsemide

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

Clé InChI

NGBFQHCMQULJNZ-UHFFFAOYSA-N

Informations sur le gène

human ... SLC12A1(6557)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Torsemide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Torsemide Tablets
  • Torsemide Compounded Oral Suspension

Actions biochimiques/physiologiques

Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Mentions de danger

H319,H361fd

Classification des risques

Eye Irrit. 2 - Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

James J DiNicolantonio
Future cardiology, 8(5), 707-728 (2012-09-28)
Furosemide is the most widely prescribed loop diuretic in the setting of systolic heart failure (HF), yet torsemide has been shown to have less inter- and intra-individual variation in bioavailability and a longer duration of action compared with furosemide. Thus
S F Fowler et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 52(16), 1771-1780 (1995-08-15)
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of torsemide are reviewed. Torsemide belongs to the pyridine-sulfonylurea class of loop diuretics. Its primary site of activity is the thick ascending limb of the loop of Henle, where
J S Blose et al.
The Annals of pharmacotherapy, 29(4), 396-402 (1995-04-01)
To review the clinical pharmacology of torsemide and to compare it with currently available loop diuretics, particularly furosemide. An English-language MEDLINE search, 1985 to October 1994, was used to identify pertinent literature, including review articles. Data from scientific literature were
Loop diuretics: comparison of torsemide, furosemide, and bumetanide.
B P Chen
Connecticut medicine, 60(6), 343-345 (1996-06-01)

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