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Y0002263

N-Nitroso-diisopropylamine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

N-(1-Methylethyl)-N-nitroso-2-propanamine solution

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About This Item

Formule empirique (notation de Hill):
C6H14N2O
Numéro CAS:
601-77-4
Poids moléculaire :
130.19
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Fabricant/nom de marque

EDQM

Concentration

in methanol

Application(s)

pharmaceutical

Température de stockage

2-8°C

InChI

1S/C6H14N2O/c1-5(2)8(7-9)6(3)4/h5-6H,1-4H3

Clé InChI

AUIKJTGFPFLMFP-UHFFFAOYSA-N

Catégories apparentées

Description générale

This product is provided as delivered and specified by European Pharmacopoeia. For further information and support, including product information leaflets, please go to the website of the issuing Pharmacopeia.

Application

N-Nitroso-diisopropylamine EP reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

It is also used to prepare N-Nitrosamines spiking solution to detect the concentration of N-nitrosamines in active substances according to the monograph 20542 of European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes,Central nervous system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

49.5 °F

Point d'éclair (°C)

9.7 °C

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Certificats d'analyse (COA)

Lot/Batch Number

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Articles

Determination of N-Nitrosamines in Valsartan

Nitrosamines have been discovered as a serious contaminant group in active pharmaceutical ingredients (API) belonging to the sartan family. This article describes a GC-MS method for the determination of nitrosamines in Valsartan tablets according to US FDA guide lines that can be used for pharma QC.

LC-MS/MS Analysis of N-Nitrosodimethylamine in Valsartan Dispersible Tablets using a Titan™ C18 UHPLC column

Learn about LC-MS/MS method development to quantify NDMA impurity in valsartan drug substance using Titan™ C18 column based UHPLC separation

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