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Key Documents

T6830

Sigma-Aldrich

Thyroglobulin human

Synonyme(s) :

Thyroglobulin human

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About This Item

Numéro CAS:
9010-34-8
Numéro CE :
232-721-3
Numéro MDL:
MFCD01324794
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.56

Source biologique

human

Niveau de qualité

200

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized solid

Technique(s)

cell culture | mammalian: suitable

Numéro d'accès UniProt

P01266

Température de stockage

2-8°C

Informations sur le gène

human ... TG(7038)

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Description générale

Human Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyryonine. Patients with Hashimoto′s thyroiditis or Grave′s disease, frequently develop antibodies against human Thyroglobulin.
Human Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyryonine. Patients with Hashimoto′s thyroiditis or Graves′ disease, frequently develop antibodies against human Thyroglobulin. Thryoglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer and in Graves′ disease.

Actions biochimiques/physiologiques

Thyroglobulin has been shown to induce expression of platelet activating factor in human peripheral blood mononuclear cells which is found elevated in some patients with thyroid disease.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Ricardo Adaixo et al.
Nature communications, 13(1), 61-61 (2022-01-12)
The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of triiodothyronine (T3) and thyroxine
E Resetkova et al.
Regional immunology, 4(4), 204-208 (1992-07-01)
Platelet activating factor (PAF), a phospholipid mediator, has been found to play a role in immune reactions, as well as in many pathophysiological alterations in certain disorders. To determine whether there might be a potential role of PAF in the
C Nascimento et al.
European journal of endocrinology, 169(5), 689-693 (2013-08-14)
Thyroglobulin (Tg) measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients; however, in patients who do not undergo radioactive iodine (RAI) ablation, normal ultrasensitive Tg levels measured under levothyroxine treatment (usTg/l-T4) are not well defined.
Rodrigo Moreno-Reyes et al.
The Journal of clinical endocrinology and metabolism, 98(9), 3694-3701 (2013-07-13)
Many countries in Europe remain mildly iodine deficient but relatively few country-level data exist on mild iodine deficiency (MID) and its impact on thyroid function in pregnant women. To determine the prevalence of thyroid disorders in pregnant women in Belgium
Sif Gudbrandsdottir et al.
Journal of immunology (Baltimore, Md. : 1950), 191(8), 4059-4067 (2013-09-21)
Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG)
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A validated amino acid analysis assay for accurate quantification of stable isotope labeled protein reference materials: SIL thyroglobulin case study

With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance.

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