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T9265

Sigma-Aldrich

Thyrotropic hormone from human pituitary

lyophilized powder, ≥6.2 IU/mg (immunoassay, non-sterile)

Synonyme(s) :

hTSH, TSH, Thyroid stimulating hormone

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About This Item

Numéro CAS:
9002-71-5
Numéro MDL:
MFCD00132432
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32

Source biologique

human pituitary glands

Niveau de qualité

200

Stérilité

non-sterile

Forme

lyophilized powder

Activité spécifique

≥6.2 IU/mg (immunoassay, non-sterile)

Conditions de stockage

(Keep container tightly closed in a dry and well-ventilated place)

Technique(s)

cell culture | mammalian: suitable

Impuretés

HIV-1/HIV-2, tested negative

Numéro d'accès UniProt

P01222
P16473

Conditions d'expédition

ambient

Température de stockage

−20°C

Informations sur le gène

human ... TSHB(7252) , TSHR(7253)

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Description générale

Research area: Cell Signaling

Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.

Application

Thyrotropic hormone from human pituitary has been used as a supplement in the fetal thyroid organoid culture medium for stimulating maturation. It has also been used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.

Actions biochimiques/physiologiques

In children, thyroid hormones are very much essential for the normal cognition and neurodevelopment. Thyroid-stimulating hormone (TSH) test is mainly used to diagnose thyroid function.
The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer celllines.TSHR activated by TSH activates both the adenosine 3′,5′-cyclic monophosphate (cAMP) pathway (via Gsa) and the phosphoinositol/calcium (IP/Ca2+; via Gq) second messenger signaling pathway by interacting with Gs and Gq G-proteins. In mature adipocytes, TSH aids in lipid metabolism by inhibiting fatty acid synthase (FASN) expression via, activating protein kinase A (PKA)-dependent phosphorylation of extracellular signal-regulated kinases/p42/p44 (ERK1/2), and c-Jun N-terminal kinase (JNK).
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Conditionnement

Package size based on hormone

Forme physique

Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.

Anticorps

Réf. du produit
Description
Tarif

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

D Manole et al.
The Journal of clinical endocrinology and metabolism, 86(3), 1072-1077 (2001-03-10)
Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid tumors. In a very recent study a direct growth stimulatory effect of
Impact of light exposure on thyroid-stimulating hormone results using the Siemens Advia Centaur TSH-3Ultra assay
Armer J, et al.
Annals of Clinical Biochemistry, 54(5), 612-615 (2017)
Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships
Szkudlinski MW, et al.
Physiological Reviews, 82(2), 473-502 (2002)
J Carretero et al.
Histology and histopathology, 4(1), 71-76 (1989-01-01)
The TSH-producing adenohypohyseal cells of Wistar rats were studied after treatment with orally administered methymazole by the PAP immunocytochemical method. These cells were compared with those of normal animals. The effects of methymazole were different in the females to those
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