SML3635

AGX51

≥98% (HPLC)

• Synonyme(s) : AGX 51, AGX-51, N-[3-(1,3-Benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-(phenylmethyl)propenamide, N-[3-(1,3-Benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide
• Formule empirique (notation de Hill): C₂₇H₂₉NO₄
• Numéro CAS: 330834-54-3
• Poids moléculaire : 431.52
• Numéro MDL: MFCD02241518
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: oil
• Couleur: , colorless to light yellow
• Température de stockage: 2-8°C

Description

Actions biochimiques/physiologiques

AGX51 is an antagonist that blocks transcriptional regulators ID1-4 from binding basic helix-loop-helix (bHLH) transcription factor E47, causing ubiquitin-mediated degradation of IDs (10-40 μM for 2-48h; HCT116). AGX51 reduces cell viability, G0/G1 growth arrest, and a reduction in cyclin D1 levels in cultures (5-40 μM for 4-24h; HUVEC and HCT116) and suppresses ocular neovascularization in mouse models of age-related macular degeneration (AMD) and retinopathy of prematurity (ROP) in vivo (500 μg/mouse via twice daily i.p. or 1-30 μg/eye via intravitreal injection immediately and 7 days after rupture of Bruch’s membrane).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable