SML1142

VU0071063

≥98% (HPLC)

• Synonyme(s) : 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
• Formule empirique (notation de Hill): C₁₈H₂₂N₄O₂
• Numéro CAS: 333415-38-6
• Poids moléculaire : 326.39
• Numéro MDL: MFCD02648040
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825676
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 10 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CN(C1=C2N(CC3=CC=C(C(C)(C)C)C=C3)C=N1)C(N(C)C2=O)=O
• InChI: 1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3
• Clé InChI: ZFZAIHKQJBMYLO-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

VU0071063 is a potent activator of Kir6.2/SUR1 KATP channels (EC₅₀ = 10.3 μM). VU0071063 reversibly inhibits glucose-stimulated calcium influx in mouse β-islet cells. The compound VU0071063 has no affect on Kir6.2/SUR2A channels.

VU0071063 is also known as [7-(4-(tert-butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione]. It serves as a major compound for examining β-cell physiology, K_ATP channel gating and a new chemical scaffold for evolving enhanced activators with medicinal chemistry.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable