SAE0192

Parathyroid Hormone (1-84) Human

Recombinant expressed in E. coli

• Synonyme(s) : PTH, Parathormone
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Escherichia coli
• Niveau de qualité: 100
• Produit recombinant: expressed in E. coli
• Essai: ≥95% (SDS-PAGE)
• Forme: solid
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

Parathyroid hormone (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium in the blood, whereas calcitonin (a hormone produced by the parafollicular cells of the thyroid gland) acts to decrease calcium concentration.
Parathyroid Hormone 1-84 (full length) Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 84 amino acids (MW of ∼9.4kDa) with the following amino acid sequence:
SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ

Actions biochimiques/physiologiques

PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptor in three parts of the body: In the bones- It enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Recombinant Human full length PTH 1-84 has potential as an anti-osteoporotic agent, due to its properties as a bone formation stimulant, it increases bone turnover, stimulating osteoblasts and reducing both vertebral and non-vertebral fractures.

Forme physique

The product is supplied as lyophilized powder, from a 0.2μm filtered concentrated solution in PBS pH7.4.

Stockage et stabilité

It is recommended to reconstitute the lyophilized PTH in sterile purified water, at not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
Upon reconstitution PTH should be stored at 2-8 °C up to 7 days and for future use at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid freeze-thaw cycles

Clause de non-responsabilité

This product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable