SAB4502493
Anti-PTHR1 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
PTH1 Receptor, PTH1R, PTHR, Parathyroid hormone 1 receptor
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About This Item
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 52 kDa
Espèces réactives
rat, mouse, human
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... PTH1R(5745)
Description générale
Anti-PTHR1 antibody detects endogenous levels of total PTHR1 protein.
PTHR1 (parathyroid hormone 1 receptor) gene is mapped to human chromosome 3p21.31. The gene encodes for a precursor (secretin-like class II G protein-coupled receptor) that matures to a receptor containing 593 amino acids. This receptor contains an extracellular loop with a PTH binding site and an intracellular signaling domain. It also includes seven transmembrane and helical segments. The gene is predominantly expressed in osteoblasts and renal tubular cells.
Immunogène
The antiserum was produced against synthesized peptide derived from human PTHR1.
Immunogen Range: 145-194
Immunogen Range: 145-194
Actions biochimiques/physiologiques
Heterozygous mutation of PTHR1 (parathyroid hormone 1 receptor) gene is known to cause primary failure of tooth eruption in human, with partial eruption of posterior teeth and reduced alveolar growth process. PTHR1 is associated with bone remodeling (bone formation and resorption, anabolic and catabolic responses respectively) and calcium homeostasis. Blomstrand chondrodysplasia results due to complete loss of PTHR1 function, and is considered lethal.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
A novel homozygous PTH1R variant identified through whole-exome sequencing further expands the clinical spectrum of primary failure of tooth eruption in a consanguineous Saudi family.
Jelani M.
Archives of Oral Biology, 67, 28-33 (2016)
Katja Braun et al.
Physiological reports, 6(17), e13842-e13842 (2018-09-11)
An active lifestyle is generally recommended for hypertensive patients to prevent subsequent end-organ damage. However, experimental data on long-term effects of exercise on hypertension are insufficient and underlying mechanisms are not well understood. This study was aimed to investigate the
VMP1 Establishes ER-Microdomains that Regulate Membrane Contact Sites and Autophagy.
Tabara LC and Escalante R
PLoS ONE, 11(11), 1-20 (2016)
Lei Xiong et al.
EBioMedicine, 9, 45-60 (2016-06-23)
Parathyroid hormone (PTH) plays critical, but distinct, roles in bone remodeling, including bone formation (anabolic response) and resorption (catabolic response). Although its signaling and function have been extensively investigated, it just began to be understood how distinct functions are induced
Samantha R Weaver et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(5), 986-999 (2021-01-13)
Endochondral ossification is tightly controlled by a coordinated network of signaling cascades including parathyroid hormone (PTH). Pleckstrin homology (PH) domain and leucine rich repeat phosphatase 1 (Phlpp1) affects endochondral ossification by suppressing chondrocyte proliferation in the growth plate, longitudinal bone
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