SAB4700622
Monoclonal Anti-Ly6g-FITC antibody produced in rat
clone RB6-8C5, purified immunoglobulin, buffered aqueous solution
Synonyme(s) :
Anti-Gr-1, Anti-Gr1, Anti-Ly-6G
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rat
Conjugué
FITC conjugate
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
RB6-8C5, monoclonal
Forme
buffered aqueous solution
Espèces réactives
mouse
Concentration
1 mg/mL
Technique(s)
flow cytometry: suitable
Isotype
IgG2b
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
mouse ... Ly6g(546644)
Description générale
Lymphocyte antigen 6 complex, locus G (Ly6G) is a 25kDa glycosylphosphatidylinositol (GPI)–anchored protein. It is encoded by the gene mapped to mouse chromosome 15. The encoded protein belongs to the Ly6/urokinase plasminogen activator receptor (uPAR) family. Ly6G is characterized with a “3 finger fold” motif stabilized by 4-5 disulfide bonds. Ly6G is expressed only in mice.
The rat monoclonal antibody RB6-8C5 detects Ly6G component of Gr-1 antigen, a commonly used surface marker of neutrophils.
Immunogène
Murine granulocytes
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Actions biochimiques/physiologiques
The protein folds of lymphocyte antigen 6 complex, locus G (Ly6G) help to form a docking site for other molecules. Ly6G functions as a marker for neutrophils. The encoded protein might be implicated in the modulation of leukocyte migration.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Ly6G ligation blocks recruitment of neutrophils via a β2-integrin?dependent mechanism
Wang JX
Blood, 120, 1489-1498 (2012)
Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo
Yipp BG and Kubes P
Blood, 121, 241-242 (2013)
Ly6 family proteins in neutrophil biology
Lee PY
Journal of Leukocyte Biology, 94, 585-594 (2013)
Yangyang Zhang et al.
Diabetes, 69(7), 1549-1561 (2020-04-30)
Diabetic keratopathy, a sight-threatening corneal disease, comprises several symptomatic conditions including delayed epithelial wound healing, recurrent erosions, and sensory nerve (SN) neuropathy. We investigated the role of neuropeptides in mediating corneal wound healing, including epithelial wound closure and SN regeneration.
Yong Woo Jung et al.
European journal of immunology, 39(8), 2281-2292 (2009-07-14)
Th2 lymphocytes deliver essential signals for induction of asthmatic airway inflammation. We previously found that airway antigen challenge induces recruitment of Gr-1(+) neutrophils prior to the recruitment of Th2 cells. We examined, therefore, whether Gr-1(+) cells contribute to the development
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