SAB4503882

Anti-phospho-IKK-α (pSer¹⁷⁶) /IKK-β (pSer¹⁷⁷) antibody produced in rabbit

affinity isolated antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 84 kDa
• Espèces réactives: rat, human, mouse
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:1000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Numéro d'accès NCBI: O14920; O15111
• Numéro d'accès UniProt: O15111
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer176/pSer177)
• Informations sur le gène: human ... CHUK(1147) , IKBKB(3551)

Description

Description générale

CHUK (conserved helix-loop-helix ubiquitous kinase) is located on human chromosome 10q24. IKK1/IKK-α has three ordered protein domains, namely, a kinase domain (KD), a ubiquitin-like domain (ULD) and a scaffold dimerization domain (SDD). IKKB (inhibitor of nuclear factor κ B kinase subunit β) is mapped to human chromosome 8p11. IKBKB codes for IκB kinase 2 (IKK2/IKKβ). IKK1 and IKK2 has a canonical MAP kinase kinase (MAPKK) activation loop motif.

Immunogène

The antiserum was produced against synthesized peptide derived from human IKK-alpha around the phosphorylation site of Ser177.

Immunogen Range: 151-200

Actions biochimiques/physiologiques

IKK1/IKKα (I-κ-B kinase 1) modulates nuclear factor κ-B (NF-κB) signaling, that is required for lymphoid organogenesis and adaptive immunity. IκB kinase α (IKKα) plays a major role in human skin cancer. This gene also controls terminal differentiation and multiplication of keratinocytes. IKKβ acts as the master regulator of cell survival and the inflammatory response.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable