SAB4503789
Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit
affinity isolated antibody
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 58 kDa
Espèces réactives
human, mouse, rat
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
phosphorylation (pSer40)
Informations sur le gène
human ... TH(7054)
Description générale
Tyrosine Hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5, close to the insulin (INS) and Harvey-ras-1 (HRAS) genes. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end.
Immunogène
The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Ser40.
Immunogen Range: 41-90
Immunogen Range: 41-90
Actions biochimiques/physiologiques
Tyrosine Hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson′s disease (PD). Point mutation in the gene coding for TH leads to Segawa′s syndrome.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
K L O'Malley et al.
Nucleic acids research, 16(10), 4437-4446 (1988-05-25)
The gene for the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin (INS) and for the oncogene Harvey Ras 1 (HRAS). Here we show that
S Colette Daubner et al.
Archives of biochemistry and biophysics, 508(1), 1-12 (2010-12-24)
Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. Modes of
Christopher Tolleson et al.
CNS & neurological disorders drug targets, 11(4), 381-386 (2012-04-10)
Tyrosine hydroxylase (TH) is the rate limiting step in the biosynthesis of dopamine and other catecholamines. Differences have been noted in concentration and availability of this enzyme and its cofactors in disease states such as Parkinson's disease (PD) which are
Akira Nakashima et al.
Biochemical and biophysical research communications, 407(2), 343-347 (2011-03-12)
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its N-terminus plays a critical role in the intracellular stability of the enzyme. In the present study, we investigated the mechanism by which the N-terminal region of TH affects
B Lüdecke et al.
Human genetics, 95(1), 123-125 (1995-01-01)
We have examined the molecular basis of Segawa's syndrome in six families with seven affected children. In one family two siblings with this disease carried a point mutation in exon 11 of the tyrosine hydroxylase gene, resulting in an amino
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