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S3134

Sigma-Aldrich

Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)

lyophilized powder, ≥2,000 units/mg solid

Synonyme(s) :

Streptokinase from Streptococcus hemolyticus

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About This Item

Numéro CAS:
9002-01-1
Numéro de classification (Commission des enzymes):
3.4.99.0 (BRENDA, IUBMB)
Numéro CE :
232-647-1
Numéro MDL:
MFCD00082037
Code UNSPSC :
12352204
eCl@ss :
32160410
Nomenclature NACRES :
NA.54

Forme

lyophilized powder

Activité spécifique

≥2,000 units/mg solid

Conditions d'expédition

wet ice

Température de stockage

−20°C

InChI

1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)

Clé InChI

XRZWVSXEDRYQGC-UHFFFAOYSA-N

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Description générale

Research area: Cell signaling

Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.

Application

Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.
Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.

Actions biochimiques/physiologiques

Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.

Définition de l'unité

One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.

Forme physique

Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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André Busch et al.
International journal of molecular sciences, 21(17) (2020-09-06)
During total joint replacement, high concentrations of mesenchymal stromal cells (MSCs) are released at the implantation site. They can be found in cell-tissue composites (CTC) that are regularly removed by surgical suction. A surgical vacuum suction handle was filled with
Ansar S Zhalyalov et al.
PloS one, 12(7), e0180668-e0180668 (2017-07-08)
Fibrinolysis is a cascade of proteolytic reactions occurring in blood and soft tissues, which functions to disintegrate fibrin clots when they are no more needed. In order to elucidate its regulation in space and time, fibrinolysis was investigated using an
Effects of plasminogen and streptokinase on the vital functions of nervous tissue cells in culture
Nikandrov, V., et al.
Biomeditsinskaia Khimiia, 54, 192-200 (2012)
Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East
Al-Zakwani, I., et al.
Journal of the American Medical Association, 34(3), 445-451 (2012)
Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?
D Collen et al.
Blood, 84(3), 680-686 (1994-08-01)
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