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R0775

RANK/Fc Chimera from mouse

Name: RANK/Fc Chimera from mouse
Brand: SIGMA

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonyme(s) :

Osteoclast differentiation receptor, ODFR, Receptor activator of NF-κB

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About This Item

Numéro MDL:

MFCD03703131

Code UNSPSC :

51111800

Nomenclature NACRES :

NA.32

Source biologique

mouse

Niveau de qualité

200

Produit recombinant

expressed in NSO cells

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

10.12 μg/mL EC₅₀

Poids mol.

60 kDa

Conditionnement

pkg of 1 mg

Conditions de stockage

avoid repeated freeze/thaw cycles

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Numéro d'accès UniProt

O35305

Température de stockage

−20°C

Informations sur le gène

mouse ... Tnfrsf11a(21934)

Application

RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF-ΚB and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis.

Actions biochimiques/physiologiques

TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Remarque sur l'analyse

The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis.

N Nakagawa et al.

Biochemical and biophysical research communications, 253(2), 395-400 (1999-01-08)

Osteoclast differentiation factor (ODF) is a ligand for osteoclastogenesis-inhibitory factor/osteoprotegerin (OCIF/OPG), and mediates an essential signal for osteoclastogenesis. Soluble-form ODF binds directly to osteoclast progenitors, suggesting the presence of a membrane-bound receptor for ODF (ODFR) on the cells. To understand

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

D M Anderson et al.

Nature, 390(6656), 175-179 (1997-11-21)

Dendritic cells are rare haematopoietic cells that reside in a number of organs and tissues. By capturing, processing and presenting antigens to T cells, dendritic cells are essential for immune surveillance and the regulation of specific immunity. Several members of

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