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P9357

Sigma-Aldrich

Anti-Potassium Channel Kv1.5 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-ATFB7, Anti-HCK1, Anti-HK2, Anti-HPCN1, Anti-KV1.5, Anti-PCN1

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About This Item

Numéro MDL:
MFCD02097213
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

mouse, rat

Technique(s)

western blot (chemiluminescent): 1:200-1:400

Numéro d'accès UniProt

Q61762

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Kcna5(16493)
rat ... Kcna5(25470)

Description générale

Pivotal role of potassium channel is maintaining cell volume, membrane potential and neuronal excitability. Two families of potassium channel exists- one with inwardly rectifying potassium channel and the other with voltage sensing (KV) big conductance, calcium activated (BKCA ) small conductance and calcium activated (SK) potassium channel. KV1.5 channel is O2 sensitive, so hypoxia inhibits the expression of KV1.5 channel through 15-HETE pathway. Anti-Potassium Channel Kv1.5 antibody reacts specifically with full length Kv1.5 protein of rat and mouse.

Immunogène

GST fusion protein from the C-terminal of mouse potassium channel Kv1.5 corresponding to amino acids 513-602.

Application

Anti-Potassium Channel Kv1.5 antibody can be used in immunocytochemistry, immunoblotting and immunofluorescence.

Forme physique

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.05% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Gloria Juliana Rey-Parra et al.
American journal of respiratory and critical care medicine, 178(4), 399-406 (2008-05-31)
Neonatal chronic lung disease (CLD), caused by prolonged mechanical ventilation (MV) with O(2)-rich gas, is the most common cause of long-term hospitalization and recurrent respiratory illness in extremely premature infants. Recurrent episodes of hypoxemia and associated ventilator adjustments often lead
Xiaojie Chu et al.
Prostaglandins & other lipid mediators, 88(1-2), 42-50 (2008-11-06)
Hypoxia initiated pulmonary vasoconstriction is due to the inhibition of voltage-gated K(+) (K(V)) channels. But the mechanism is unclear. We have evidence that hypoxia activates 15-lipoxygenase (15-LOX) in distal pulmonary arteries and increases the formation of 15-hydroxyeicosatetraenoate (15-HETE). 15-HETE-induced pulmonary
B Attali et al.
The Journal of biological chemistry, 268(32), 24283-24289 (1993-11-15)
The mouse Kv1-5 K+ channel cDNA has been cloned from heart. This channel was highly expressed in heart and, to a lesser extent, in other tissues, including brain and thymus. Two alternatively spliced isoforms were found. The longer form encoded
R Swanson et al.
Neuron, 4(6), 929-939 (1990-06-01)
Rat brain cDNA and genomic clones encoding three K+ channels, Kv1, Kv2, and Kv3, have been isolated by screening with Shaker probes and encode proteins of 602, 530, and 525 amino acids. Each of the deduced protein sequences contains six

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