P8615

Phosphoinositide 3-kinase p110γ human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

• Synonyme(s) : PI3K p110γ human, Phosphatidylinositol 3-kinase p110γ human
• Numéro MDL: MFCD03457993
• Code UNSPSC : 12352207
• Nomenclature NACRES : NA.32

Propriétés

• Produit recombinant: expressed in baculovirus infected insect cells
• Niveau de qualité: 200
• Pureté: ≥95% (SDS-PAGE)
• Forme: buffered aqueous glycerol solution
• Activité spécifique: ~4.5 units/mg protein
• Numéro d'accès UniProt: P48736
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... PIK3CG(5294)

Description

Description générale

Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3. PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.

Actions biochimiques/physiologiques

PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.

Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma. Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers. Mutation in the gene is associated with the development of autistic disorder.

PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.

Définition de l'unité

1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate.

Forme physique

Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable