Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

View All Documentation

P4620

Sigma-Aldrich

PD 146176

≥98% (HPLC), solid

Synonyme(s) :

6,11-Dihydro[1]benzothiopyrano[4,3-b]indole

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C15H11NS
Numéro CAS:
4079-26-9
Poids moléculaire :
237.32
Numéro MDL:
MFCD05664738
Code UNSPSC :
51111800
ID de substance PubChem :
24724579
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

solid

Couleur

white to beige

Solubilité

DMSO: soluble >10 mg/mL
H2O: insoluble

Chaîne SMILES 

C1Sc2ccccc2-c3[nH]c4ccccc4c13

InChI

1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2

Clé InChI

ZGOOPZVQMLHPFM-UHFFFAOYSA-N

Informations sur le gène

human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)

Application

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Actions biochimiques/physiologiques

PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
15-Lipoxygenase inhibitor

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 2

1 of 2

Erastin ≥98% (HPLC)

Sigma-Aldrich

E7781

Erastin

Déféroxamine mesylate salt powder, ≥92.5% (TLC)

Sigma-Aldrich

D9533

Déféroxamine mesylate salt

Jiang Yang et al.
Scientific reports, 9(1), 13316-13316 (2019-09-19)
Ovarian cancer (OvCa), while accounting for only 3% of all women's cancer, is the fifth leading cause of cancer death among women. One of the most significant obstacles to successful OvCa treatment is chemoresistance. The current lack of understanding of
David M Tobin et al.
PloS one, 8(7), e67828-e67828 (2013-07-23)
While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory state and tuberculosis susceptibility. Here
Yoo Jin Na et al.
Cancers, 11(11) (2019-11-14)
Despite the importance of radiation therapy, there are few radiation-related markers available for use in clinical practice. A larger catalog of such biomarkers is required to help clinicians decide when radiotherapy should be replaced with a patient-specific treatment. Arachidonate 15-lipoxygenase
Manuela Schneider et al.
Neoplasia (New York, N.Y.), 12(3), 254-263 (2010-03-18)
The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogenesis. Therefore, we hypothesized a putative regulatory role of GPx4 during tumor progression and created
Haider H Dar et al.
The Journal of clinical investigation, 128(10), 4639-4653 (2018-09-11)
Ferroptosis is a death program executed via selective oxidation of arachidonic acid-phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues, ferroptosis has been pathogenically associated with brain, kidney, and liver injury/diseases. We discovered that a prokaryotic bacterium, Pseudomonas aeruginosa, that

Contenu apparenté

Discover Bioactive Small Molecules for Lipid Signaling Research

Discover Bioactive Small Molecules for Lipid Signaling Research

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique