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N7155

Sigma-Aldrich

Anti-Nitric Oxide Synthase, Brain (251-270) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

Anti-bNOS

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About This Item

Numéro MDL:
MFCD01092427
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 150-160 kDa

Espèces réactives

human, rat

Technique(s)

microarray: suitable
western blot: 1:10,000 using rat brain extract

Numéro d'accès UniProt

P29475

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NOS1(4842)
rat ... Nos1(24598)

Description générale

Nitric Oxide Synthase, Brain (NOS1) is mapped to human chromosome 12q24.22. The NOS isoform found in neurons is a 150 kDa protein. It is also termed as brain NOS (bNOS). Human bNOS and endothelial NOS (eNOS) share 52% amino acid identity, and rat and human bNOS share 93% amino acid identity.

Immunogène

synthetic peptide corresponding to nitric oxide synthase (NOS) of rat brain origin (bNOS, amino acids 251-270) conjugated to KLH. The immunogen sequence is highly conserved in human bNOS.

Application

Anti-Nitric Oxide Synthase, Brain (251-270) antibody produced in rabbit has been used in:
  • double immunolabelling,
  • immunofluorescence
  • western blotting

Actions biochimiques/physiologiques

Nitric Oxide Synthase, Brain (bNOS) is present also in skeletal muscle, where it is complexed with dystrophin and is absent in Duchenne muscular dystrophy (DMD). Neuronal and endothelial NOS are constitutively expressed and are dependent on Ca2+ calmodulin for nitric oxide (NO) production.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

nNOS-expressing neurons in the ventral tegmental area and substantia nigra pars compacta
Paul EJ, et al.
eNeuro, 5(5), 100-100 (2018)
Expression of nitric oxide synthase in the retina of monocular deprivation amblyopia rats
Wang QM, et al.
European Review for Medical and Pharmacological Sciences, 22(7), 1879-1883 (2018)
Daniel S Zahm et al.
The Journal of comparative neurology, 519(16), 3159-3188 (2011-05-28)
The midbrain dopaminergic neuronal groups A8, A9, A10, and A10dc occupy, respectively, the retrorubral field (RRF), substantia nigra compacta (SNc), ventral tegmental area (VTA), and ventrolateral periaqueductal gray (PAGvl). Collectively, these structures give rise to a mixed dopaminergic and nondopaminergic
Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution
Claude S
Mammalian Genome (1998)
Reciprocal variations of nNOS and HSP90 are associated with fasting in gastrointestinal tract of the piglet
Jean-Francois G
Digestive Diseases and Sciences (2003)
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