M2449

MB-3

≥95% (HPLC)

• Synonyme(s) : γ-butyrolactone, Butyrolactone 3, (2R,3S)-rel-4-Methylene-5-oxo-2-propyltetrahydrofuran-3-carboxylic acid
• Formule empirique (notation de Hill): C₉H₁₂O₄
• Poids moléculaire : 184.19
• Numéro MDL: MFCD08702690
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817942
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥95% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: H₂O: ≥10 mg/mL; DMSO: ≥20 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
• InChI: 1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1
• Clé InChI: SRQUTZJZABSZRQ-RQJHMYQMSA-N

Description

Application

MB-3 has been used as a general control non-repressible 5 (GCN5) inhibitor:

• to study its effects on lamin A/C-associated pY19-Cav-2-mediated histone H3 acetylations
• to analyze its effects on the growth of Arabidopsis thaliana seedlings
• to study its effects on craniofacial chondrocyte maturation

Actions biochimiques/physiologiques

MB-3 can modify the gene expression in murine embryonic stem cells as well as yeast. It hinders the acetyltransferase activity of general control non-repressible 5 (GCN5) by binding to acetyl CoA pocket present in GCN5.

MB-3 is a Gcn5 HAT (Histone Acetyltransferase) inhibitor; anti-inflammatory, anti-carcinogenic.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable