M1434

2-Methylthioadenosine 5′-monophosphate triethylammonium salt hydrate

solid, ≥98% (HPLC)

• Synonyme(s) : 2-MeSAMP, 2-Methylthio-AMP triethylammonium salt hydrate
• Formule empirique (notation de Hill): C₁₁H₁₆N₅O₇PS · xC₆H₁₅N × yH₂O
• Numéro CAS: 22140-20-1
• Poids moléculaire : 393.31 (anhydrous free acid basis)
• Code UNSPSC : 41106305
• eCl@ss : 32160414
• ID de substance PubChem : 24896647
• Nomenclature NACRES : NA.51

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: H₂O: 20 mg/mL, clear, colorless
• Température de stockage: −20°C
• Chaîne SMILES: O.CCN(CC)CC.CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1
• InChI: 1S/C11H16N5O7PS.C6H15N.H2O/c1-25-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(23-10)2-22-24(19,20)21;1-4-7(5-2)6-3;/h3-4,6-7,10,17-18H,2H2,1H3,(H2,12,14,15)(H2,19,20,21);4-6H2,1-3H3;1H2/t4-,6-,7-,10-;;/m1../s1
• Clé InChI: YQMUWWZKFZERBT-IDIVVRGQSA-N

Description

Application

2-Methylthioadenosine 5′-monophosphate triethylammonium salt hydrate has been used:

• as a P2Y₁₂ inhibitor to study its effects on stimulation of endocytosis in high-density lipoprotein (HDL).
• as a P2Y₁₂ inhibitor to study its effects on platelet recruitment in whole human blood.

Actions biochimiques/physiologiques

2-Methylthioadenosine5′-monophosphate triethylammonium salt (2-MeSAMP) is an adenosine-based P2Y₁₂ antagonist and ADP-dependent platelet aggregation inhibitory agent.(1) It has a potential to inhibit platelet activation throughP2Y₁₂/G(i)-dependent mechanism.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)