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K3761

Sigma-Aldrich

KT 5720

≥98% (HPLC), powder

Synonyme(s) :

(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester

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About This Item

Formule empirique (notation de Hill):
C32H31N3O5
Numéro CAS:
108068-98-0
Poids moléculaire :
537.61
Numéro MDL:
MFCD00132118
Code UNSPSC :
51111800
ID de substance PubChem :
24896235
Nomenclature NACRES :
NA.77

Source biologique

microbial

Niveau de qualité

200

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to faint yellow

Solubilité

methanol: 5 mg/mL

Conditions d'expédition

wet ice

Température de stockage

−20°C

Chaîne SMILES 

CCCCCCOC([C@@]1(O)C[C@@]2([H])N3C(C=CC=C4)=C4C5=C3C6=C(C(C=CC=C7)=C7N6[C@]1(C)O2)C8=C5C(NC8)=O)=O

InChI

1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1

Clé InChI

ZHEHVZXPFVXKEY-IKZDWWSZSA-N

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Application

KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2 stimulation of tumor-associated Vascular endothelial growth factor (VEGF) expression.

Actions biochimiques/physiologiques

Specific, cell-permeable inhibitor of protein kinase A (PKA). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK).

Caractéristiques et avantages

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Elizabeth A Townsend et al.
American journal of physiology. Lung cellular and molecular physiology, 303(10), L923-L928 (2012-09-25)
Clinically observed differences in airway reactivity and asthma exacerbations in women at different life stages suggest a role for sex steroids in modulating airway function although their targets and mechanisms of action are still being explored. We have previously shown
Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line
Ishida E, et al.
PLoS ONE, 7(12), e50918-e50918 (2012)
Swidbert R Ott et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(7), E381-E387 (2011-12-21)
The mechanisms that integrate genetic and environmental information to coordinate the expression of complex phenotypes are little understood. We investigated the role of two protein kinases (PKs) in the population density-dependent transition to gregarious behavior that underlies swarm formation in
Yi-hung CHEN et al.
Acta pharmacologica Sinica, 31(12), 1553-1563 (2010-11-03)
to investigate the effects of 2'-hydroxy-4'-methoxyacetophenone (paeonol) on the electrophysiological behavior of a central neuron (right parietal 4; RP4) of the giant African snail (Achatina fulica Ferussac). intracellular recordings and the two-electrode voltage clamp method were used to study the
Elizabeth M Forbes et al.
Neuron, 74(3), 490-503 (2012-05-15)
Correct guidance of axons to their targets depends on an intricate network of signaling molecules in the growth cone. Calcium and cAMP are two key regulators of whether axons are attracted or repelled by molecular gradients, but how these molecules
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