E9505

β-Estradiol 3-sulfate sodium salt

≥93%

• Synonyme(s) : 1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate
• Formule linéaire : C₁₈H₂₃O₅SNa
• Numéro CAS: 4999-79-5
• Poids moléculaire : 374.43
• Numéro MDL: MFCD00056553
• Code UNSPSC : 12352200
• ID de substance PubChem : 24894699
• Nomenclature NACRES : NA.77

Propriétés

• Stérilité: non-sterile
• Niveau de qualité: 200
• Pureté: ≥93%
• Forme: powder
• Contient: ~70% N-methyl-D-glucamine as stabilizer
• Solubilité: methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: [Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24
• InChI: 1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1
• Clé InChI: PYPVMTJYMKHIST-LBARCDFESA-N

Description

Description générale

β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.

Application

β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.

Actions biochimiques/physiologiques

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.

Conditionnement

Package size based on steroid content

Informations sur la sécurité

• Pictogrammes: GHS07,GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H332 - H351
• Conseils de prudence: P202 - P261 - P264 - P301 + P312 - P304 + P340 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges