D9035

Diazoxide

≥98% (TLC), powder, ATP-sensitive K⁺ channel activator

• Synonyme(s) : 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Formule empirique (notation de Hill): C₈H₇ClN₂O₂S
• Numéro CAS: 364-98-7
• Poids moléculaire : 230.67
• Numéro CE : 206-668-1
• Numéro MDL: MFCD00078578
• Code UNSPSC : 12352119
• ID de substance PubChem : 24277831
• Nomenclature NACRES : NA.77

Propriétés

• product name: Diazoxide,
• Forme: powder
• Niveau de qualité: 100
• Solubilité: 0.1 M NaOH: soluble; H₂O: insoluble; methanol: soluble
• Auteur: Schering Plough
• Chaîne SMILES: CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
• InChI: 1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
• Clé InChI: GDLBFKVLRPITMI-UHFFFAOYSA-N
• Informations sur le gène: human ... KCNA1(3736) , KCNJ11(3767) , KCNJ8(3764) , KCNMA1(3778) ; mouse ... Kcnj1(56379) , Kcnj11(16514) ; rat ... Gria1(50592) , Kcna1(24520) , Kcnj1(24521) , Kcnj11(83535) , Kcnj8(25472)

Description

Description générale

Diazoxide is a nondiuretic benzothiadiazine, which is used for the treatment of hypoglycemia, von Gierke′s disease, acute and malignant hypertension. It acts as a beta cell K_ATP channel opener. Diazoxide prevents the secretion of insulin.

Application

Diazoxide has been used for diazoxide infusion. It has also been used to prevent depolarization for K⁺-induced exocytosis.

Actions biochimiques/physiologiques

Selective ATP-sensitive K⁺ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.

Caractéristiques et avantages

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319,H335
• Conseils de prudence: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves