D7000

Deoxycorticosterone acetate

• Synonyme(s) : 21-hydroxy-4-pregnène-3,20-dione 21-acétate, 4-Pregnène-21-ol-3,20-dione 21-acétate, Cortexone acétate, DOC acétate
• Formule empirique (notation de Hill): C₂₃H₃₂O₄
• Numéro CAS: 56-47-3
• Poids moléculaire : 372.50
• Numéro Beilstein : 2570798
• Numéro CE : 200-275-9
• Numéro MDL: MFCD00003660
• Code UNSPSC : 12352200
• ID de substance PubChem : 24894065
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Stérilité: non-sterile
• Pureté: ≥98% (HPLC)
• Forme: powder
• Solubilité: H₂O: insoluble; acetone: soluble (1 in 30); alcohol: soluble (1 in 50); chloroform: freely soluble; dioxane: slightly soluble; vegetable oils: slightly soluble
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O
• InChI: 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
• Clé InChI: VPGRYOFKCNULNK-ACXQXYJUSA-N
• Informations sur le gène: human ... NR3C2(4306)

Description

Description générale

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

Application

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)